Dede Koswara, 42, from Indonesia, reached worldwide notoriety through a string of documentaries because of his scaly skin condition.
But the dad, whose warts grew from his feet and hands like tree roots, died on Saturday (January 30).
Dede suffered from ultra-rare disease Lewandowsky-Lutz dysplasia, a form of uncontrolled human papilloma virus infections – or otherwise warts.
US medics once removed 6kg in warts from his body in 2008.
The operation meant he could play Sudoku, wear flip-flops and press buttons on a phone.
But the infection grew back and he needed two more surgeries a year to contain them.
His wife of ten years also left him because he couldn’t support them and their two kids.
A doctor said he died due to a complicated string of health problems including hepatitis, liver and gastric disorders.
“He was coping with his illness, even though people despised him as someone cursed.
“He was bored, resting in bed in the hospital, and often smoked to pass the time.
“He wanted to go back to being a carpenter and starting a home business.
Medics also announced on Saturday that they will try treating the wart-like disease which plagues Bangladeshi Rickshaw puller Ajul Bajandar.
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