Sturridge is left out of the squad after suffering cramps at the end of Sunday's Capital One Cup final when City emerged victorious on penalties.
He is one of five changes Jurgen Klopp makes to his side.
Kolo Toure and Dejan Lovren come in for the injured Lucas and Mamadou Sakho in the heart of defence while Jon Flanagan replaces Alberto Moreno.
Adam Lallana starts in place of Philippe Coutinho, Liverpool's goalscorer on Sunday.
City have made three changes, Joe Hart coming in for penalty hero Willy Caballero while Pablo Zabaleta and Jesus Navas replace Bacary Sagna and Yaya Toure.
And Raheem Sterling starts on his first return to Anfield since his acrimonious move to City last summer.
Liverpool: Mignolet, Clyne, Toure, Lovren, Flanagan, Henderson, Can, Milner, Lallana, Firmino, Origi.
Substitutes: Ward, Skrtel, Moreno, Allen, Ibe, Coutinho, Benteke.
Manchester City: Hart, Zabaleta, Clichy, Kompany, Otamendi, Fernando, Fernandinho, Navas, Silva, Sterling, Aguero
Substitutes: Caballero, Sagna, Demichelis, Kolarov, Bony, Iheanacho, Mangala
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